DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection
نویسندگان
چکیده
منابع مشابه
HLA-A2-restricted protection against lethal lymphocytic choriomeningitis.
The consequences of human lymphocytic choriomeningitis virus (LCMV) infection can be severe, including aseptic meningitis in immunocompetent individuals, hydrocephalus or chorioretinitis in fetal infection, or a highly lethal outcome in immunosuppressed individuals. In murine models of LCMV infection, CD8(+) T cells play a primary role in providing protective immunity, and there is evidence tha...
متن کاملProtection against Respiratory Syncytial Virus Infection by DNA Immunization
Respiratory syncytial virus (RSV) remains a major cause of morbidity and mortality in infants and the elderly and is a continuing challenge for vaccine development. A murine T helper cell (Th) type 2 response associates with enhanced lung pathology, which has been observed in past infant trials using formalin-inactivated RSV vaccine. In this study, we have engineered an optimized plasmid DNA ve...
متن کاملHuman Infection with Lymphocytic Choriomeningitis Virus
Lung contusions and pandemic (H1N1) 2009 can cause ARDS (6,7). We do not know the relative role of each in causing the ARDS that our patient had, but the severity of clinical symptoms, although the lung injury was judged to be only of moderate magnitude, suggests that infl uenza played a major role in the development of his acute lung disease. The infection with oseltamivir-resistant virus, for...
متن کاملEncephalitis Syndrome of Lymphocytic Choriomeningitis Virus Infection.
Studies on Eaton PPLO Pneumonia ELLI JANSSON, 0. WAGER, R. STENSTROM, E. KLEMOLA, AND P. FORSSELL ... ... ... ... 142 Sensitivities of Colonies and Suspensions of Actinomyces Israelii to Penicillins, Tetracyclines, and Erythromycin G. C. BLAKE ... ... ... ... 145 Comparison of Ampicillin and Chloramphenicol in Treatment of Paratyphoid Fever R. A. SLEET, G. SANGSTER, AND J. MCC. MURDOCH ... ... ...
متن کاملVaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.
DNA vaccination was evaluated with the experimental murine model of Trypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the trypomastigote surface antigen 1 (TSA-1), a target of anti-T. cruzi antibody and major histocompatibility complex (MHC) class I-restricted CD8(+) cytotoxic T-lymphocyte (CTL) responses, was used as the model antigen. Following the intramu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1995
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.69.4.2684-2688.1995